A Functional Near-Infrared Spectroscopy Study

Association Among SNAP-25 Gene DdeI and MnlI Polymorphisms and Hemodynamic Changes During Methylphenidate Use: A Functional Near-Infrared Spectroscopy StudyÖzgür Öner, Ata Akın, Hasan Herken, Mehmet Emin Erdal, Koray Çiftçi, Mustafa Ertan Ay, Duygu Bicer, Bedriye Öncü, Ozlem Hekim Bozkurt, Kerim Münir, Yankı YazganObjective: To investigate the interaction of treatment-related hemodynamic changes with genotype status for Synaptosomal associated protein 25 (SNAP-25) gene in participants with attention deficit hyperactivity disorder (ADHD) on and off single dose short-acting methylphenidate treatment with functional near-infrared spectroscopy (fNIRS). Method: A total of 15 right-handed adults and 16 right-handed children with DSM-IV diagnosis of ADHD were evaluated. Ten milligrams of short-acting methylphenidate was administered in a crossover design. Results: Participants with SNAP-25 DdeI T/T genotype had decreased right deoxyhemoglobin () with treatment. SNAP-25 MnlI genotype was also associated with right deoxyhemoglobin () and changes as well as left change. When the combinations of these genotypes were taken into account, the participants with <ddei c/c or t/c and mnli g/g or t/g>ddei c/c or t/c and mnli g/g or t/g> genotype had increased right with MPH use whereas the participants with <ddei t/t and mnli t/t>ddei t/t and mnli t/t> or <ddei t/t and mnli g/g or t/g>ddei t/t and mnli g/g or t/g> genotypes had decreased right prefrontal . Conclusions: These results suggested that SNAP-25 polymorphism might be associated with methylphenidate induced brain hemodynamic changes in ADHD participants.Reference: Öner, Ö., Akin, A., Herken, H., Erdal, M. E., Çiftçi, K., Ay, M. E., Bicer, D., Öncü, B., Bozkurt, O. H., Münir, K., & Yazgan, Y. (2010). Association among SNAP-25 gene DdeI and MnlI polymorphisms and hemodynamic changes during methylphenidate use: a functional near-infrared spectroscopy study. .